A key goal of our drug discovery research is tackling antimicrobial resistance through the identification of bioactive compounds from plants that have the potential to become therapeutic agents in the treatment of tuberculosis
Antibiotic-resistant Mycobacterium tuberculosis strains are jeopardizing efforts in eradicating the global Tuberculosis crisis. Mycobacterium tuberculosis is inherently resistant to many antibiotics limiting the number of compounds accessible for therapy. This inherent resistance is caused by several mechanisms. A key goal of our drug discovery research is tackling antimicrobial resistance through the identification of bioactive compounds from plants that have the potential to become therapeutic agents in the treatment of tuberculosis. Our team leverages core expertise in assay development, high-throughput screening, hit-to-lead medicinal chemistry and in vivo pharmacology to expedite the drug discovery process. Our drug discovery…… Read more
Amengor, Cedric Dzidzor Kodjo, Emmanuel Orman, Cynthia Amaning Danquah, Inemesit Okon Ben, Prince Danan Biniyam, and Benjamin Kingsley Harley. 2022. Pyridine-N-Oxide Alkaloids from Allium stipitatum and Their Synthetic Disulfide Analogs as Potential Drug Candidates against Mycobacterium tuberculosis: A Molecular Docking, QSBAR, and ADMET Prediction Approach. BioMed research international 2022. Read more | |
Cedric Dzidzor Kodjo Amengor, Cynthia Amaning Danquah, Emmanuel Bentil Asare Adusei, Francis Klenam Kekessie, Francis Ofosu-Koranteng, Paul Peprah, Benjamin Kingsley Harley, Emmanuel Orman, Joseph Adu, Yussif Saaka. 2022. Synthesized Phosphonium Compounds Demonstrate Resistant Modulatory and Antibiofilm Formation Activities against Some Pathogenic Bacteria, Heteroatom Chemistry, vol. 2022, 9 pages. Read more | |
Amengor, Cedric Dzidzor Kodjo, Francis Klenam Kekessie, Abena Brobbey, John Nii Addotey, Paul Peprah, Cynthia Amaning-Danquah, Joseph Adu, Michael Tetteh, and Emmanuel Bentil Asare Adusei. 2022. Anti-Biofilm Formation Activities of 4-Hydroxyindole Azo Compounds Against Pseudomonas aeruginosa and Staphylococcus aureus. Journal of Scientific Research and Reports 28 (8)Read more | |
Amengor, Cedric D. K., Patrick Gyan, Cynthia A. Danquah, Paul Peprah, Benjamin K. Harley, Emmanuel Orman, Inemisit O. Ben, Michael Tetteh, Emmanuel B. A. Adusei, Francis K. Kekessie, and Nathaniel N. A. Okine. 2022. Antimicrobial Activity and In Silico ADME Prediction of Synthesised 8-Hydroxyquinoline Azo Compounds Against Some ESKAPE Human Pathogens and Mycobacterium smegmatis”. Journal of Pharmaceutical Research International 34 (42A), 68-80. Read more | |
Augustine Tandoh, Cynthia A. Danquah, Charles K. Benneh, Donatus W. Adongo, Eric Boakye-Gyasi and Eric Woode. 2022. Effect of Diclofenac and Andrographolide Combination on Carrageenan-Induced Paw Edema and Hyperalgesia in Rats. Dose-Response. Read more |
