A key goal of our drug discovery research is tackling antimicrobial resistance through the identification of bioactive compounds from plants that have the potential to become therapeutic agents in the treatment of tuberculosis
Antibiotic-resistant Mycobacterium tuberculosis strains are jeopardizing efforts in eradicating the global Tuberculosis crisis. Mycobacterium tuberculosis is inherently resistant to many antibiotics limiting the number of compounds accessible for therapy. This inherent resistance is caused by several mechanisms. A key goal of our drug discovery research is tackling antimicrobial resistance through the identification of bioactive compounds from plants that have the potential to become therapeutic agents in the treatment of tuberculosis. Our team leverages core expertise in assay development, high-throughput screening, hit-to-lead medicinal chemistry and in vivo pharmacology to expedite the drug discovery process. Our drug discovery…… Read more
Adu, W. A., Ativui, S., Ofori, M., Owusu, G., Danquah, C. A., & Poku‑Sampene Ossei, P. (2025). Diosgenin ameliorates silica‑induced tuberculosis in rats. Animal Models and Experimental Medicine. Advance online publication. Read more | |
Moyo, P., Bodede, O., Wooding, M., Famuyide, I. M., Makhubu, F. N., Khorommbi, N. K., Ofori, M., Danquah, C. A., McGaw, L. J., & Maharaj, V. J. (2025). Quorum sensing inhibition by South African medicinal plants species: An in vitro and an untargeted metabolomics study. BMC Complementary Medicine and Therapies, 25, Article 138. Read more | |
Sasu, P., Agbehadzi, R. K., Ackah, E. M., Adjei‑Mensah, B., Ellison, F. E., Danquah, C. A., Tona, K., Hamidu, J. A., & Were, P. (2025). Effects of six-hour pre-incubation thermal conditioning and prolonged storage on egg quality, embryogenesis, hatchability, and post-hatch physiology of Plymouth Rock hybrid chickens in tropical climate of Ghana. Journal of World’s Poultry Research, 15(1), 1–22. Read more | |
Nyarko, M.S., Danquah, C.A., Antwi, A.O., Emikpe, B.O. and Osafo, N. (2025), Aurantio-Obtusin Suppresses Airway Inflammation and Serum ICAM-1 Expression in Guinea Pig Allergic Asthma Model. Immunity, Inflammation and Disease, 13: e70160. Read more | |
Buabeng, N. K. B., Amponsah, O. K. O., Ayisi-Boateng, N. K., Atawuchugi, P., Boateng, K. E., Mohammed, A., … & Danquah, C. A. (2024). Benefits of Statins as Adjunct Therapy in the Management of Tuberculosis in Patients at a Referral Site in Ghana. medRxiv, 2024-12. Read more | |
Sallah, L., Coffie, P. N., Babatunde, D. M., Danquah, C. A., Baah, F. K., Mante, P. K., & Owusu-Daaku, K. O. (2024). Anti-implantation and uterotonic properties of Mentha pulegium L. in female Sprague-Dawley rats. International Journal of Scientific Reports, 10(10), 346–355. Read more |
